CROSPOVIDONE USP / EP /BP / IP :s
General Information :

International non-proprietary name ( INN) : Crospovidone

Chemical Name : Cross-linked homopolymer of 1-ethenylpyrrolidin-2-one

Other non-proprietary name : PVPP; Insoluble PVP; Crospovidonum; Polyvinylpolypyrrolidone

Cas No : [25249-54-1]

Molecular Structure :

Molecular Formula :

(C 6H 9NO) n

Application :
Pharmaceutical Industry :
  1. Provide rapid disintegration in a wide range of oral solid dosage formulations and processes.

  2. Ideally suited for use with poorly compressible drug actives and in direct compression tablet processes.

  3. Outstanding performance in manufacturing ionic, acidic and alkaline drug actives.

  4. Quick dissolve and chewable tablets.

  5. Treat gastrointestinal disorders and as an anti-diarrhea agent.

  6. Can also be used to improve solubility, and hence, enhance bioavailability in not only human but also veterinary applications.
Beverage Industry :

PVP-P can be used in

  1. Improving the quality and extends the shelf-life of beer by absorbing the polyphenyls and tannoids.

  2. Prevention of 'pinking' and 'browning' reactions in white and sparkling wines.

  3. Enhanced aroma and flavor in red wines.

  4. cost-effective and safe treatment in beer industry that.

  5. Completely insoluble in beer.

  6. Applicable to all types of beer.

  7. Higher efficacy - lower dosage.

  8. Easy to use and excellent handling characteristics.

  9. Insoluble process aids, with wide regulatory approval.

  10. No negative impact on foam, flavor or other quality parameters.

  11. Improved dispersion and sedimentation characteristics.

  12. Longer filter run lengths compared to silica alone.

  13. Uses existing plant equipment.
ANALYTICAL SPECIFICATION OF CROSPOVIDONE USP / EP / BP / IP :

TEST

STANDARDS

APPEARANCE

A White to yellowish white powder

IDENTIFICATION : A + B + C + D

Positive

PH VALUE

5.0 to 8.0

PEROXIDE, AS H2O2

NMT 400 ppm

WATER SOLUBLE SUBSTANCES

NMT 1.0%

VINYLPYRROLIDONE

NMT 10 ppm

HEAVY METALS

NMT 10 ppm

WATER

NMT 5.0 %

LOSS ON DRYING

NMT 5.0%

SULPHATED ASH

NMT 0.1%

NITROGEN CONTENT (ASSAY)

11.0 – 12.8%

RESIDUAL SOLVENTS

No class I, class II & class III solvents are present in this product as listed in the current USP <467>

 
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CROSPOVIDONE USP / EP /BP / IP